There is increasing concern for a 31-year-old woman reported missing from her home in Stonehouse, near Stroud, on Friday July 16.
Phillipa Verity Burns, of Pearcroft Road, was last seen at 11.30am and was reported missing to police at 2.20pm.
She is considered vulnerable, and needs to take essential medication which she does not have with her.
Officers have reason to believe she may have travelled to the Devizes area of Wiltshire.
Phillipa is described as being white, five foot six inches tall and of heavy build. She has blond, straight, shoulder length hair, and blue eyes. She has a pitted complexion and smokes.
Anyone who sees Phillipa should ring Gloucestershire Police on 0845 090 1234.
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